TABLE 1.
Clinical Features of the Study Groups
| Preoperative Crohn’s Disease (n=17) |
Preoperative Ulcerative Colitis (n=261) |
|
|---|---|---|
| Sex (M/F) | 11/6 | 156/105 |
| Median age in years | 45 (13–64) | 38 (7–81) |
| Median disease duration in months |
101 (24–636) | 72 (1–600) |
| Disease extent (%) | ||
| Pancolitisa | 12 (71) | 200 (76) |
| Left-sided | 5 (29) | 61 (24) |
| Preoperative medication (%) | ||
| Steroids alone | 2 (12) | 34 (13) |
| Immunomodulators | 4 (23) | 176 (67) |
| Biologics | 11 (65) | 51 (20)b |
| Extraintestinal disease (%) | ||
| Arthritis | 2 (12) | 42 (16) |
| PSC | 0 | 8 (3) |
| Other | 0 | 13 (5) |
| Family history of IBD (%) | 3 (18) | 63 (24) |
| Smoking history (%) | 4 (24) | 81 (31) |
| Indication for IPAA (%) | ||
| Medically unresponsive | 15 (88) | 209 (80) |
| Cancer/dysplasia | 2 (12) | 52 (20) |
| Surgical Treatment | ||
| 2-stage IPAA | 7 (41) | 196 (75) |
| 3-stage IPAA | 10 (59) | 65 (25)c |
| Preoperative features of CD (%) | ||
| Small bowel disease | 5 (29) | — |
| Noncaseating granuloma | 5 (29) | — |
| Discontinuous inflammation | 3 (18) | — |
| Perianal disease | 4 (24) | — |
a
Pancolitis included skip lesions in CD patient group.
b
P = 0.0001.
c
P = 0.004.
Values in parentheses except range denote percentage.
PSC, primary sclerosing cholangitis; IBD, inflammatory bowel disease; IPAA, ileal pouch-anal anastomosis; CD, Crohn’s disease.