Table 1.
Selected Responses to Cyclic Stretch in Cultured Epithelial Cells (See Also Figure 22).
| Reference No. | Authors (year) | Description | Frequency (cycles/min) |
|---|---|---|---|
| (8) | Arold et al. (2009) | Phospatidyl choline (PC) secretion and cell death | 3 |
| (28) | Budinger et al. (2008) | Activation of 5′ AMP-activated protein kinase (AMPK) | 30 |
| (38) | Chapman et al. (2005) | Increased reactive oxygen species (ROS) production | 30 |
| (44) | Cohen et al. (2010) | Mitogen-activated protein kinase (MAPK) activation and tight junction protein expression | 15 |
| (56) | Desai et al. (2008) | Inhibition of migration | 10-30 |
| (63) | dos Santos et al. (2004) | Changes in gene expression | 30 |
| (72) | Edwards et al. (1998) | Induction of apoptosis and PC secretion | 3 |
| (79) | Felder et al. (2007) | Increased cytokeratin 8-ser431 phosphorylation and plasma membrane injury | N/A |
| (84) | Fisher and Margulies (2002) | Increased Na+-K+-ATPase activity | 15 |
| (93) | Frick et al. (2004) | Increased Ca2+ release and lactate dehydrogenase (LDH) threshold | N/A |
| (98) | Geiger et al. (2009) | Increased tubulin acetylation, cytoskeletal reorganization, and apoptosis | 15 |
| (99) | Geiger et al. (2006) | Cytoskeletal reorganization, decreased polymerized tubulin | 30 |
| (105) | Hammerschmidt et al. (2007) | Increased apoptosis | 20 |
| (107) | Hammerschmidt et al. (2005) | Increased inflammatory response | 40 |
| (127) | Jafari et al. (2004) | Decreased glutathione, increased IL-8 and IL-6 (glutathione dependent) | 20 |
| (129) | Jones et al. (2005) | MAPK activation transduced by laminin-6 | 30 |
| (145) | Lam and Dean (2008) | Increased gene traficking | 30 |
| (165) | McAdams et al. (2006) | Increased proliferation (normoxia) and decreased cell death (hyperoxia) | 30 |
| (183) | Ning and Wang (2007) | Increased IL-8 production | N/A |
| (193) | Patel et al. (2005) | Increased PC release in ATII but not ATI-like cells; increased ATP release in ATI-like cells. | N/A |
| (194) | Patel and Kwon (2009) | Increased nitric oxide production | 12 |
| (203) | Pugin et al. (2008) | Increased acidification and bacterial growth | 20 |
| (210) | Ren et al. (2009) | Increased cell death, F-actin reorganization, morphological remodeling | N/A |
| (259) | Tschumperlin and Margulies (1998) | Increased cell death | 15 |
| (261) | Tschumperlin et al. (2000) | Increased cell injury | 15-60 |
| (267) | Vlahakis et al. (1999) | Increased IL-8 release | 20 |
| (278) | Waters et al. (1999) | Increased Na+-K+-ATPase activity | 30 |
| (291) | Wirtz and Dobbs (1990) | Increased surfactant release | N/A |
| (293) | Wu et al. (2009) | Increased pentraxin 3 release | 18 |
| (300) | Yerrapureddy et al. (2010) | Changes in gene expression | 15 |