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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: J Immunol. 2010 Jun 28;185(3):1642–1649. doi: 10.4049/jimmunol.1000091

FIGURE 2.

FIGURE 2

Exposure to A/PR/8/34 and A/FM/1/47 induces protective immunity against A/California/04/09. Cohorts of BALB/c mice were sublethally infected intranasally with 0.1 × LD50 live mouse-adapted A/PR/8/34 and A/FM/1/47 influenza viruses. We collected sera from these mice at days 7, 14, and 28 and determined their A/California/04/09-specific IgG titers (A) and HAI titers (B). One month later, these mice were challenged with 3 × LD50 live mouse-adapted A/California/04/09 virus and monitored for survival up to 14 d postchallenge (C). Body weight changes, indicative of morbidity, were also monitored up to 14 d (D). The graphs represent the mean ± SEM.