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. 2015 Jun 2;108(11):2623–2632. doi: 10.1016/j.bpj.2015.04.018

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Suggested scenario. (a) The formation of microthrombi at a corner or at branching points can drastically impair the hemodynamics, due to a possible severe restriction of the lumen area. (b) Example of aggregate detachment (blood sample 8 at 25% hematocrit): when reaching a critical size, cellular aggregates can break. Scale bar, 20 μm. (c) Free flowing aggregate in microcirculation. Relative velocity of an aggregate flowing along a 20-μm-wide channel. Initial velocity is 200 μm/s and SRBCs were from blood sample 8 at 25% hematocrit. (Open arrows) Direction of the flow. To see this figure in color, go online.