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. 2015 Jun 2;108(11):2633–2647. doi: 10.1016/j.bpj.2015.04.028

Figure 2.

Figure 2

Probe stimulation versus ideal stimulation (simulation). (Top plots) Top-down view of the hair bundle. Arrows indicate the stimulated stereocilia either by the probe-contact (A and C) or the tectorial membrane. (Middle plots) States of individual transduction channels along the time (filled spans indicate the open state); channel colors correspond to the stereocilia colors in the top plots. (Bottom plots) Normalized whole cell transduction current. Ten-to-twenty trials were averaged to reduce the stochastic noise of the Monte Carlo simulation. (Thick black line) Overall normalized transduction current. (Red, green, and thin black lines) Sum of channel activities in middle plots. (A) OHC stereocilia subjected to 0.2-μm probe-displacement. (B) OHC stereocilia tips subjected to 0.1 μm of uniform displacement along stereocilia columns. (C) IHC stereocilia subjected to 0.25-μm probe-displacement. (D) IHC stereocilia subjected to 0.1 μm of uniform displacement along stereocilia columns. The stimulation is considered a step displacement because it is ramped faster (τ = 20 μs) than the adaptation of mechano-transduction. To see this figure in color, go online.