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. 2015 Jun 2;108(11):2633–2647. doi: 10.1016/j.bpj.2015.04.028

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Effect of horizontal connector stiffness (simulation). OHC stereocilia bundle with different levels of horizontal connector stiffness (k_HC2) was stimulated with the standard probe in Fig. 1. (A) When k_HC2 = 25 mN/m. Scale bar, 0.4 μm. (B) When k_HC2 = 1 mN/m. Scale bar, 0.4 μm. (C) Normalized splay of the OHC hair bundles with different horizontal connector stiffnesses (0 = no splay, or complete coherence; 1 = no coherence at all). (D) Normalized transduction current versus hair bundle displacement. The ideal case is when the tallest row stereocilia are evenly deflected.