Fig. 4.

Schematic representation of Dab1 variants. Dab1 exons are shown (exons are not drawn to scale). The start codon is located in exon 2, whereas the stop codon is located in exon 14. Exons 3–6 encode the PTB domain, while exons 6–9 encode the four critical tyrosine phosphorylation motifs. Exclusion of exons 7 and/or 8 in mice or exons 8 and 9 in zebrafish results in partial deletion of tyrosine phosphorylation motifs in Dab1. Inclusion of exons 9b/9c results in an in-frame 33 aa insertion. Inclusion of an alternative exon after exon 7 in Dab1²¹⁷ results in deletion of two tyrosine motifs and introduction of an in-frame stop codon generating a 217-aa product. Inclusion of an alternative exon after exon 9 in Dab1²⁷¹ introduces an in-frame codon generating a 271-aa product