Table 1.
Alternatively spliced Dab1 isoforms
| Species | Alternative splicing events | Sequence difference relative to the canonical Dab1 | Ref. |
|---|---|---|---|
| Chicken | Exclusion of exons 7 and 8 and inclusion of exon 9b | Deletion of 35 aa containing Y198, Y200 and Y220, insertion of 19 aa | [31, 65] |
| Pig | Exclusion of exons 7 and 8 and inclusion of exons 9b and 9c | Deletion of 35 aa containing Y198, Y200 and Y220, insertion of 33 aa | [71] |
| Lizard | Inclusion of exon 9b | Insertion of 19 aa | [67] |
| Zebrafish | Exclusion of exons 8 and 9 | Deletion of 42 aa containing Y200, Y220 and Y232 | [68] |
| Human | Alternative promoter usage | NA | [67] |
| Human | Exclusion of exons 7 and 8 and inclusion of exons 9b and 9c | Deletion of 35 aa containing Y198, Y200 and Y220, insertion of 33 aa | [70] |
| Mouse | Exclusion of exon 7 | Deletion of 13 aa containing Y198 | [63] |
| Mouse | Exclusion of exon 8 | Deletion of 22 aa containing Y200 and Y220 | [63] |
| Mouse | Exclusion of exons 7 and 8 | Deletion of 35 aa containingY198, Y200 and Y220 | [63] |
| Mouse | Inclusion of exons 9b and 9c | Insertion of 33 aa | [63, 66, 67, 69] |
| Mouse | Exclusion of exons 7 and 8 and inclusion of exons 9b and 9c | Deletion of 35 aa containing Y198, Y200 and Y220, insertion of 33 aa | [63] |
| Mouse | Exclusion of exon 8, inclusion of exons 9b and 9c | Deletion of 22 aa containing Y200 and Y220, insertion of 33 aa | [63] |
| Mouse | Alternative 5′ splice site of intron 9 | Deletion of 2 aa (valine and serine) | [63] |
| Mouse | Alternative 5′ splice site of intron 9, exclusion of exons 7 and 8 | Deletion of 2 aa (valine and serine), deletion of 35 aa containing Y198, Y200 and Y220 | [63] |
| Mouse | Alternative 5′ splice site of intron 9, inclusion of exons 9b and 9c | Deletion of 2 aa (valine and serine), insertion of 33 aa | [63] |
| Mouse | Alternative 5′ splice site of intron 9, exclusion of exons 7 and 8, inclusion of exons 9b and 9c | Deletion of 2 aa (valine and serine), deletion of 35 aa containingY198, Y200 and Y220, insertion of 33 aa | [63] |
| Mouse | Alternative 5′ splice site of intron 9, exclusion of exons 7 and 8 | Deletion of 2 aa (valine and serine), deletion of 35 aa containingY198, Y200 and Y220 | [63] |
| Mouse | Alternative 5′ splice site of intron 9, inclusion of exons 9b and 9c | Deletion of 2 aa (valine and serine), insertion of 33 aa | [63] |
| Mouse | Alternative 5′ splice site of intron 9, exclusion of exons 7 and 8, inclusion of exons 9b and 9c | Deletion of 2 aa (valine and serine), deletion of 35 aa containing Y198, Y200 and Y220 and insertion of 33 aa | [63] |
| Mouse | Inclusion of exon 7a | Addition of 18 aa with a stop codon | [69] |
| Mouse | Inclusion of exon 9a | Addition of 31 aa with a stop codon | [69] |