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. 2015 Jun 5;10(6):e0129417. doi: 10.1371/journal.pone.0129417

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© 2015 Stetzner et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — Presented are the levels of TNF-α (A), INF-γ (B), IL-6 (C), and IL-1β (D) at skin infection sites and levels of IL-6 and TNF-α (E) and INF-γ (F) in sera at the indicated time points after subcutaneous inoculation of 2.1 x 10⁸ cfu MGAS315 and 2.7 x 10⁸ cfu MGAS6180. Statistical analyses with the two-tailed Mann-Whitney t test for the cytokine levels between MGAS315 and MGAS6180 infections: ns, not significant; ***, P < 0.001; **, P < 0.01; and *, P < 0.05.