Table 1.
| A: Discovery Set: Non-Hispanic White Participants with Type 1 Diabetes (N=346) from the SEARCH for Diabetes in Youth Study, Clinical Characteristics and Family History of diabetes | ||||
|---|---|---|---|---|
| All n=346 |
Females n=216 (62%) |
Males n=130 (38%) |
p-Value* | |
| Age at diagnosis (y) [Mean (SD)] | 8.5 (4.2) | 8.5 (3.9) | 8.4 (4.7) | 0.7 8 |
| Age at study visit (y) [Mean (SD)] | 13.9 (4.0) | 13.8 (4.1) | 14.1 (4.0) | 0.66 |
| Disease duration (y) [Mean (SD)] | 5.0 (4.5) | 4.9 (4.5) | 5.1 (4.4) | 0.43 |
| TPO-Ab (IU/L) [Mean (SD)] | 15.9 (10.0) | 16.0 (10.1) | 15.6 (9.3) | 0.75 |
| Additional diagnosis [n (%)] | ||||
| Hypothyroidism | 55/346 (16%) | 39/216 (18%) | 16/129 (12%) | 0.18 |
| Hyperthyroidism | 24/345 (7%) | 17/216 (8%) | 7/129 (5%) | 0.51 |
| Vitiligo | 6/343 (1.7%) | 3/215 (1.4%) | 3/128 (2.3%) | 0.68 |
| Addison disease | 1/345 (0.3%) | 1/216 (0.5%) | 0 | 1 |
| Celiac disease | 0 | 0 | 0 | - |
| Family History of DM [n (%)] | ||||
| Mother | 21/344 (6%) | 9/215 (4%) | 12/129 (9%) | 0.065 |
| Father | 20/340 (6%) | 12/214 (6%) | 8/126 (6%) | 1.00 |
| Maternal grandfather | 52/324 (16%) | 33/198 (17%) | 18/128 (14%) | 0.64 |
| Maternal grandmother | 58/335 (17%) | 34/208 (16%) | 24/127 (19%) | 0.40 |
| Paternal grandfather | 55/318 (17%) | 33/199 (17%) | 22/119 (18%) | 0.76 |
| Paternal grandmother | 53/318 (16%) | 29/207 (14%) | 24/121 (20%) | 0.21 |
| Age at the time of Diagnosis DM (years, Mean (SD)] | ||||
| Mother | 24.7 (11.8) | 25.3 (11.2) | 24.4 (12.5) | 0.99 |
| Father | 31.7 (15.9) | 31.5 (15.3) | 32.0 (18.1) | 0.95 |
| Maternal grandfather | 55.1 (15.8) | 57.5 (13.5) | 51.0 (18.8) | 0.55 |
| Maternal grandmother | 54.6 (14.3) | 52.5 (16.5) | 58.9 (6.0) | 0.78 |
| Paternal grandfather | 56.2 (16.5) | 57.9 (16.0) | 54.3 (17.5) | 0.44 |
| Paternal grandmother | 51.0 (21.6) | 52.4 (23.0) | 49.4 (20.5) | 0.52 |
| B: Replication set Patients Characteristics | ||||
|---|---|---|---|---|
| All n=185 |
Females n=128 (70%) |
Males n=57 (30%) |
||
| Age of diagnosis (y) [Mean (SD)] | 19.7 (14.3) | 20.5 (15.4) | 17.9 (11.5) | |
| Age of inclusion (y) [Mean (SD)] | 43.5 (14.5) | 46.1 (14.5) | 37.8 (12.6) | |
| Additional diagnosis [n (%)] | ||||
| Hashimotos’ Thyroiditis | 146/185 (79%) | 108/128 (84%) | 38/57 (67%) | |
| Graves’ Disease | 39/185 (21%) | 20/128 (16%) | 19/57 (33%) | |
n, Number, y, Years, SD, Standard Deviation. TPO-Ab, Thyroid Peroxydase Antibodies, DM, Diabetes Mellitus (any type)
*
p-Values are for comparing Females vs. Males
n, Number, y, Years, SD, Standard Deviation.