Table 2.
Combined association analysis in the Discovery and Replication sets in 22 genes that showed nominal association (p<0.05) in at least one SNP for the Replication set
| Discovery Set | Replication Set | Meta P | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | CHR | GENE | BP | Risk Allele |
P | OR | P | OR | P | OR |
| rs1270942 | 6 | CFB | 32,026,839 | C | 9.02 × 10−11 | 2.371 | 4.13 × 10−18 | 4.923 | 4.65 × 10−25 | 3.0494 |
| rs1150752 | 6 | TNXB | 32,172,704 | G | 2.03 × 10−13 | 2.804 | 1.81 × 10−23 | 59.57 | 2.27 × 10−24 | 3.8666 |
| rs2857595 | 6 | NCR3 | 31,676,448 | T | 1.17 × 10−06 | 1.734 | 2.20 × 10−22 | 3.717 | 1.87 × 10−23 | 2.3765 |
| rs2251396 | 6 | MICA | 31,472,686 | T | 7.37 × 10−11 | 1.92 | 1.11 × 10−14 | 2.893 | 9.87 × 10−23 | 2.2132 |
| rs1015166 | 6 | TAP2 | 32,906,709 | T | 1.88 × 10−11 | 1.925 | 5.57 × 10−13 | 2.62 | 3.84 × 10−22 | 2.1428 |
| rs1980493 | 6 | BTNL2 | 32,471,193 | G | 1.83 × 10−10 | 2.211 | 3.61 × 10−12 | 3.093 | 1.57 × 10−20 | 2.5034 |
| rs3099844 | 6 | HCP5 | 31,556,955 | A | 5.70 × 10−10 | 2.229 | 1.33 × 10−12 | 3.502 | 3.94 × 10−20 | 2.6093 |
| rs2476601 | 1 | PTPN22 | 114,179,091 | A | 2.88 × 10−11 | 2.384 | 8.63 × 10−11 | 3.637 | 7.35 × 10−20 | 2.7073 |
| rs3131296 | 6 | NOTCH4 | 32,280,971 | A | 4.48 × 10−08 | 1.983 | 5.72 × 10−13 | 3.325 | 3.27 × 10−18 | 2.389 |
| rs3115663 | 6 | BAT2 | 31,709,822 | G | 3.70 × 10−10 | 2.027 | 2.69 × 10−09 | 2.413 | 8.72 × 10−18 | 2.1609 |
| rs2227956 | 6 | HSPA1L | 31,886,251 | T | 6.32 × 10−15 | 0.2047 | 2.09 × 10−3 | 0.4768 | 1.99 × 10−15 | 0.2912 |
| rs886424 | 6 | IER3 | 30,889,981 | A | 5.96 × 10−07 | 1.894 | 1.04 × 10−09 | 3.006 | 2.89 × 10−14 | 2.2107 |
| rs3130564 | 6 | PSORS1C1 | 31,209,653 | T | 2.04 × 10−05 | 1.601 | 1.23 × 10−10 | 2.708 | 5.75 × 10−13 | 1.9116 |
| rs2844657 | 6 | DDR1 | 30,937,501 | C | 1.19 × 10−05 | 1.618 | 3.35 × 10−09 | 2.534 | 3.02 × 10−12 | 1.8746 |
| rs2358994 | 1 | BCL2L15 | 114,230,984 | A | 7.41 × 10−08 | 1.844 | 4.74 × 10−05 | 1.919 | 1.56 × 10−11 | 1.8688 |
| rs2071591 | 6 | NFKBIL1 | 31,623,778 | T | 6.28 × 10−06 | 1.529 | 1.72 × 10−06 | 1.895 | 1.14 × 10−10 | 1.6416 |
| rs1041981 | 6 | LTA | 31,648,763 | A | 1.30 × 10−05 | 1.507 | 8.01 × 10−07 | 1.935 | 1.50 × 10−10 | 1.637 |
| rs7679475 | 4 | GPR103 | 122,533,490 | A | 1.28 × 10−07 | 1.651 | 6.64 × 10−4 | 1.562 | 3.51 × 10−10 | 1.6198 |
| rs1111695 | 1 | PHTF1 | 114,045,422 | G | 6.95 × 10−07 | 1.586 | 5.72 × 10−3 | 1.434 | 1.65 × 10−08 | 1.5331 |
| rs2523989 | 6 | TRIM31 | 30,186,254 | A | 1.41 × 10−4 | 1.589 | 1.28 × 10−05 | 2.126 | 1.86 × 10−08 | 1.7499 |
| rs2153977 | 1 | MAGI3 | 113,881,594 | T | 2.44 × 10−4 | 1.431 | 3.74 × 10−4 | 1.611 | 4.18 × 10−07 | 1.491 |
| rs6924102 | 6 | PSMB8 | 32,919,361 | G | 7.27 × 10−07 | 1.614 | 4.64 × 10−08 | 0.4888 | 0.4578 | 1.0594 |
SNP, single nucleotide polymorphism, CHR, chromosome, BP, location on chromosome in base pairs, P, p-value, OR, odds ratio, MetaP, p-value for Meta-analysis