Table 2.
Correlation between insight deficits (i.e., unawareness and misattribution of symptoms) and activation in response to self-directed sentence stimuli with the self-referential (SR) metacue (i.e., "are they talking about you?") and other-directed sentence stimuli with the other-referential (OR) metacue (i.e., "are they talking about someone else?"). Within each significant cluster, the relative maximal voxel t value and its approximate anatomical location within 3 mm is listed; [x, y, z] = Montreal Neurological Institute (MNI) standard space coordinates (mm); negative x = left hemisphere. L = left; R = right; g = gyrus; BOLD = blood oxygen level dependent effect; WB = whole brain. Smoothness of residual field (Full Width at Half Maximum “FWHM”) = [11.8 11.9 12.2] mm. Voxel size = [3.0 3.0 3.0] mm. Search volume = 37,404 voxels = 517.9 resolution elements (resels). df = degrees of freedom. g = gyrus; lob = lobules; ant = anterior; post = posterior; inf = inferior; sup = superior; Italics = other brain regions within the cluster
| Correlation | Cluster Label |
Two- tailed FEW- corrected cluster p |
Number of voxels in cluster |
Maximal voxel t value in cluster [15 df] |
MNI coordinates of maximal voxel in cluster (mm) [x, y, z] |
Location of maximal voxel in cluster |
|---|---|---|---|---|---|---|
| SRSelf-dir vs. OROther-dir and unawareness of symptoms | A | < 0.001 | 1217 | 8.79 | −51, 9, 30 | L frontal inferior operculum Included parts of inf. & middle frontal g, insula, temporal pole, sup temporal g, pallidum, caudate and putamen. |
| B | <0.001 | 881 | 7.35 | 45, −30, 54 | R Precuneus Included parts of middle anterior cingulate g, precuneus, post cingulate, inf & sup parietal lob, supramarginal sulcus, middle temporal g and fusiform g. | |
| C | <0.001 | 491 | 5.93 | −18, −60, −18 | L lingual g Included parts of cerebellum, lingual g, fusiform g, inf temporal and parahippocampal g | |
| D | <0.01 | 251 | 5.48 | −63, −21, 18 | L inferior parietal lobule Included parts of inf. & sup. parietal lob, angular g, sup temporal g. | |
| E | <0.01 | 298 | 4.65 | −24, −60, 15 | Inferior parietal lobule Included parts of inf. & sup. parietal lob and precuneus | |
| SRSelf-dir vs. OROther-dir and misattribution of symptoms | A | <0.01 | 315 | 5.54 | −48, 15, −3 | L frontal inferior triangle Included parts of inf frontal g, sup temporal g and insula |
| B | <0.05 | 206 | 5.19 | 15, 3, −3 | R putamen Included parts of pallidum and caudate | |
| C | <.01 | 406 | 5.14 | −15, −190, 0 | L lingual g Included parts of lingual g, fusiform g, precuenus and cerebellum |