Table 2.

Hazard ratios (95% CI) for demographic and neuropathologic variables for transitions of cognitive impairment

	Stage 1→ Stage 2	Stage 1→ Stage 4	Stage 2→ Stage 3	Stage 2→ Stage 4	Stage 3→ Stage 4
Age at baseline	1.08 (1.06–1.10)*	0.99 (0.95–1.03)	1.00 (0.97–1.02)	1.02 (0.99–1.06)	1.00 (0.98–1.02)
Male sex	1.08 (0.86–1.36)	1.15 (0.73–1.81)	1.01 (0.72–1.41)	0.87 (0.52–1.43)	1.40 (1.04–1.89)*
Education	0.93 (0.91–0.96)*	1.01 (0.95–1.07)	0.99 (0.95–1.03)	1.00 (0.95–1.06)	1.03 (1.00–1.07)
AD	1.36 (1.07–1.72)*	0.40 (0.24–0.66)*	1.95 (1.30–2.92)*	0.38 (0.23–0.61)*	0.81 (0.57–1.16)
Macro infarcts	1.38 (1.12–1.72)*	0.56 (0.31–1.04)	1.50 (1.12–2.02)*	0.33 (0.18–0.62)*	0.98 (0.75–1.28)
Lewy bodies	1.17 (0.93–1.48)	0.58 (0.29–1.14)	1.48 (1.08–2.03)*	0.60 (0.31–1.16)	0.77 (0.58–1.03)

1. Stage 1, no impairment; Stage 2, mild impairment; Stage 3, moderate impairment; Stage 4, death.

2. The reference group refers to female participants with age 80 at baseline, with 15 years of education, and without any of the three neuropathologic findings.

3. *Hazard ratios that were statistically significant at α=0.05.