Table 3.
Association of pre-treatment antibody status with tumor HPV and smoking status among cases
| HPV- (Reference) N=26 |
HPV+ N=111 |
p | Adjusted ORc (95% CI) |
HPV+ >10 pack yearsd N=47 |
Pe | Adjusted ORef (95% CI) |
HPV+ ≤10 pack yearsd N=63 |
Pe | Adjusted ORef (95% CI) |
|
|---|---|---|---|---|---|---|---|---|---|---|
| No. + (%) | No. + (%) | No. + (%) | No. + (%) | |||||||
| E1 | 13 (50.0) | 66 (59.5) | 0.380 | 1.1 (0.4–2.9) | 21 (44.7) | 0.663 | 0.7 (0.2–1.9) | 44 (69.8) | 0.076 | 1.5 (0.5–4.2) |
| NE2 | 8 (30.8) | 50 (45.1) | 0.185 | 1.5 (0.6–4.0) | 19 (40.4) | 0.413 | 1.6 (0.5–4.8) | 31 (49.2) | 0.111 | 1.5 (0.5–4.3) |
| CE2 | 11 (42.3) | 68 (61.3) | 0.078 | 1.9 (0.7–5.0) | 20 (42.6) | 0.984 | 1.0 (0.3–2.8) | 47 (74.6) | 0.004 | 2.9 (1.0–8.1) |
| NE2 and/or CE2a | 11 (42.3) | 72 (64.9) | 0.034 | 2.3 (0.9–6.0) | 22 (46.8) | 0.711 | 1.2 (0.4–3.5) | 49 (77.8) | 0.001 | 3.4 (1.2–9.6) |
| E4 | 6 (23.1) | 27 (24.3) | 0.893 | 0.9 (0.3–2.6) | 10 (21.3) | 0.859 | 0.8 (0.2–2.6) | 16 (25.4) | 0.818 | 0.7 (0.2–2.4) |
| E5 | 2 (7.7) | 4 (3.6) | 0.319b | 0.3 (0–1.9) | 3 (6.4) | 1.0b | 0.6 (0.1–4.3) | 1 (1.6) | 0.203b | 0.2 (0–2.4) |
| E6 | 10 (38.5) | 66 (59.5) | 0.052 | 2.1 (0.8–5.3) | 24 (51.1) | 0.301 | 1.6 (0.6–4.6) | 42 (66.7) | 0.014 | 2.5 (0.9–7.0) |
| E7 | 11 (42.3) | 68 (61.3) | 0.078 | 1.8 (0.7–4.7) | 20 (42.6) | 0.984 | 0.9 (0.3–2.6) | 47 (74.6) | 0.004 | 2.9 (1.0–8.1) |
| E6 and/or E7a | 12 (46.2) | 88 (79.3) | 0.001 | 4.4 (1.6–12.4) | 30 (63.8) | 0.143 | 2.0 (0.7–5.7) | 57 (90.5) | <0.001 | 8.4 (2.5–27.8) |
| NE2, CE2, E6, and/or E7a | 13 (50.0) | 94 (84.7) | <0.001 | 6.5 (2.1–20.1) | 33 (70.2) | 0.087 | 2.5 (0.8–7.5) | 60 (95.2) | <0.001 | 17.5 (4.0–77.2) |
| Any Ea | 16 (61.5) | 94 (84.7) | 0.008 | 3.4 (1.0–11.4)) | 33 (70.2) | 0.450 | 1.4 (0.4–4.4) | 60 (95.2) | <0.001 | 8.0 (1.8–35.7) |
| L1 | 3 (11.5) | 6 (5.4) | 0.371b | 0.4 (0.1–1.8) | 3 (6.4) | 0.659b | 0.5 (0.1–2.7) | 3 (4.8) | 0.352b | 0.3 (0.1–2.0) |
| L2 | 0 | 0 | NC | NC | 0 | NC | NC | 0 | NC | NC |
| Any La | 3 (11.5) | 6 (5.4) | 0.371b | 0.4 (0.1–1.8) | 3 (6.4) | 0.659b | 0.5 (0.1–2.7) | 3 (4.8) | 0.352b | 0.3 (0.1–2.0) |
| Any E and/or La | 16 (61.5) | 94 (84.7) | 0.008 | 3.4 (1.0–11.5) | 33 (70.2) | 0.450 | 1.4 (0.4–4.4) | 60 (95.2) | <0.001 | 8.0 (1.8–35.7) |
a
Any positive vs. all negative
b
Fisher’s exact test
c
Adjusted for age, smoking (≤10 pack years vs. >10 pack years), N category (N0-N2a vs. N2b-N3), and subsite (tonsil/base of tongue vs. other)
d
One HPV+ case is missing pack years
e
Referent group is HPV- cases
f
Adjusted for age, N category (N0-N2a vs. N2b-N3), and subsite (tonsil/base of tongue vs. other)
NC, not calculable due to zero cells