. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: Cytokine. 2015 Jan 13;74(1):54–61. doi: 10.1016/j.cyto.2014.11.020

Table 2.

Examples of diseases associated with cytokines secreted by Th17 cells

Disease category	Human disease	Animal model	Th17 cytokines involved	References
Autoimmunity	Rheumatoid arthritis (RA)	Collagen-induced arthritis, Adjuvant-induced arthritis, SKG model	IL-17A	[10, 25, 26]
	Multiple sclerosis (MS)	Experimental autoimmune encephalomyelitis	IL-17A, IL-17F	[128, 129] [130]
	Systemic lupus erythematosus (SLE)	MRL/lpr, NZB/W F1, BXD2	IL-17A	[131, 132]
	Psoriasis	Chronic proliferative dermatitis, transgenic cutaneous overexpression of cytokines, IL-23 injection i.d.	IL-17A, IL-22	[133–135]
	Inflammatory bowel disease (IBD)	Trinitrobenzenesulfo nic acid-induced colitis, Dextran sulfate sodium-induced colitis	IL-17A, IL-17F	[136–138]
	Type 1 diabetes mellitus (T1D)	NOD mouse, STZ-induced Type 1 diabetes mellitus	IL-17A, IL-17F	[139, 140]
Allergy	Bronchial asthma	Allergen sensitization in BALB/c; RSV-induced asthma exacerbation	IL-17E (IL-25), IL-17F	[141–143]
Fungal/Bacterial infections and host defense	Chronic mucocutaneous candidiasis (CMC)	Oral/dermal infection of mice with Candida albicans	IL-17A, IL-17F	[43, 45, 46, 144]
Fungal/Bacterial infections and host defense	Pulmonary tuberculosis, pertussis, and pneumonia	Aerosol route to infect mouse, retropharyngeal instillation of the causative bacteria	IL-17A, IL-17F	[145, 146] [147]