Table 1.

Human and murine Aβ levels in various APP transgenic lines

Genotype	Age [mo]	Human Aβ 42 [fmol/g]	Human Aβ 40 [fmol/g]	Human 42:40 Ratio	Murine Aβ 42 [fmol/g]	Murine Aβ 40 [fmol/g]	Murine 42:40 Ratio	% murine Aβ of total Aβ
wt	1.5				70 ± 17	482 ± 49	0.14 ± 0.03
ko APP23	1.5	272 ± 82	1,265 ± 295	0.21 ± 0.03
APP23	1.5	176 ± 27	1,090 ± 171	0.16 ± 0.01	65 ± 8	413 ± 48	0.17 ± 0.03	28.40 ± 3.46
ko APP23	14.5	4,524,981 ± 342,125	20,640,263 ± 2,976,319	0.24 ± 0.02
APP23	14.5	5,548,173 ± 595,479	25,765,046 ± 4,007,354	0.23 ± 0.02	217,098 ± 8,667	302,720 ± 24,780	0.76 ± 0.08	1.82 ± 0.23
ko APPPS1	1.5	4,317 ± 181	2,955 ± 123	1.48 ± 0.11
APPPS1	1.5	4,549 ± 264	2,934 ± 150	1.55 ± 0.05	1,369 ± 61	357 ± 28	3.98 ± 0.34	18.88 ± 0.73
ko APPPS1	3	2,010,752 ± 190,640	871,106 ± 64,927	2.31 ± 0.15
APPPS1	3	2,088,929 ± 128,362	710,791 ± 42,286	2.96 ± 0.11	289,347 ± 15,161	25,181 ± 2060	11.80 ± 0.63	10.14 ± 0.34

Human and murine Aβ42 and Aβ40 levels were assessed by ELISA. Non-tg wildtype (wt) mice were included for baseline levels of murine Aβ. 6-8 animals were used per group (n=5 for wt mice).