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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Lung Cancer. 2015 Apr 9;89(1):43–49. doi: 10.1016/j.lungcan.2015.03.023

Table 3.

Prognostic value comparison between the PET/CT volumetric prognostic (PVP) index, TNM stage, and whole-body metabolic tumor volume.

Variables N Univariate Analysis
Multivariate Analysis*
HR [95%CI] p-value C HR [95%CI] p-value C
PVP index 328 2.72 [2.28,3.24] <0.001 0.71† 2.70 [2.16,3.37] <0.001 0.74$
ln(MTVWB) 328 1.60 [1.46,1.75]# <0.001 0.69 1.51 [1.36,1.67] <0.001 0.73
TNM Stage 328 <0.001^ <0.001^
I+II 126 (reference) (reference)
III 91 2.73 [1.96,3.79] 0.66 2.07 [1.44,2.97] 0.72
IV 111 4.55 [3.31,6.25] 3.55 [2.43,5.18]
TNM Stage 328 <0.001^ <0.001^
 IA 46 (reference) (reference)
 IB 43 2.24 [1.25,4.04] 1.94 [1.06, 3.55]
 IIA 19 2.04 [0.98,4.23] 1.94 [0.92, 4.08]
 IIB 18 3.04 [1.49,6.22] 0.67 1.97 [0.94, 4.12] 0.72
 IIIA 52 4.46 [2.56,7.79] 3.49 [1.93, 6.32]
 IIIB 39 5.35 [2.99,9.55] 3.20 [1.73, 5.92]
 IV 111 8.08 [4.83,13.51] 5.83 [3.28, 10.33]

Notes: N = number of patients; HR = Hazard Ratio; CI = Confidence Interval; C= Gönen and Heller’s K concordance statistic ln(MTVWB) is natural log-transformed whole-body metabolic tumor volume.

*

Adjusted for age, gender, treatment and histology.

†

p=0.033 for PVP index vs. ln(MTVWB); p<0.001 for PVP index vs. TNM stage (for both three- and seven-level staging).

$

p<0.01 for PVP index vs. ln(MTVWB); p<0.01 for PVP index vs. TNM stage (for both three- and seven-level staging).

#

The HR for MTVWB on the log10 scale would be exp(0.468*2.303) = 2.94, where 0.468 is the regression coefficient for ln(MTVWB) in this model and 2.303 is a conversion factor. Thus, for a 10-fold increase in MTV, the hazard of death increases by a factor of 2.94.

^

Based on a 2 degree of freedom test for the 3-level staging variable and 6 degree of freedom test for the 7-level staging variable.