Table 2.
Publicly available data resources that could be used for drug discovery, drug combination, and drug repositioning.
| Resources | Descriptions | URL |
|---|---|---|
| DrugBank | A database that combines detailed drug data with comprehensive target information over 7740 drug entries. | http://www.drugbank.ca/ |
| PharmGKB | A comprehensive resource that curates knowledge linking genetic variations, drug response, and pathways. | https://www.pharmgkb.org/ |
| FDA Orange Book | A list of approved drugs and drug combinations with their therapeutic equivalence evaluations. | http://www.accessdata.fda.gov/scripts/cder/ob/ |
| European Medicines Agency (EMA) | An agency of the European Union that report 950 human medicines and their therapeutic areas. | http://www.ema.europa.eu/ema/ |
| SIDER | A side effect database that contains information on 996 marketed medicines and their recorded adverse drug reactions. | http://sideeffects.embl.de/ |
| DrugMatrix | A toxicology reference database that store the results of thousands of highly controlled and standardized toxicological experiments. | https://ntp.niehs.nih.gov/drugmatrix |
| CMap | A collection of over 7,000 genome-wide transcriptional expression profiles from cultured human cells treated with bioactive small molecules. | https://www.broadinstitute.org/cmap/ |
| STITCH | A database of protein–chemical interactions that integrates many sources of experimental and manually curated evidence. | http://stitch.embl.de/ |
| Therapeutic Target Database (TTD) | A database to provide information about therapeutic protein and nucleic acid targets, targeted diseases, pathway information and the drugs directed at each of these targets. | http://bidd.nus.edu.sg/group/cjttd/ |
| PROMISCUOUS | A resource of protein-protein and drug- protein interactions that aims to provide a uniform data set for drug repositioning and further analysis. | http://bioinformatics.charite.de/promiscuous/ |