Table 1.
TgAb do not develop and thyroiditis is minimal in B10.A.4R and NOD.Lc7 mice after 8 or 16 weeks on regular water (Con) or water supplemented with NaI.
| Strain | Weeks | Con | n | NaI | n |
|---|---|---|---|---|---|
| TgAb (OD 490 nm; mean ± SEM) | |||||
| B10.A.4R | 8 | −0.02 ± 0.02 | 6 | −0.01 ± 0.01 | 7 |
| 16 | −0.03 ± 0.02 | 7 | −0.06 ± 0.01 | 7 | |
| NOD.Lc7 | 8 | 0.05 ± 0.01 | 9 | −0.03 ± 0.02 | 9 |
| 16 | 0.01 ± 0.03 | 9 | 0.00 ± 0.03 | 9 | |
| BALB/c | 8 | 0.00 ± 0.02 | 5 | −0.03 ± 0.01 | 15 |
| 16 | −0.28 ± 0.09 | 5 | −0.16 ± 0.06 | 15 | |
| NOD.H2h4 | 8 | 0.11 ± 0.13 | 31 | 0.65 ± 0.05 | 31 |
| 16 | 0.39 ± 0.14 | 31 | 1.07 ± 0.11 | 31 | |
| Thyroiditis (% infiltration; mean ± SEM) | |||||
| B10.A.4R | 16 | 1.0 ± 0.0 | 5 | 1.0 ± 0.0 | 6 |
| NOD.Lc7 | 16 | 1.4 ± 0.2 | 9 | 1.9 ± 0.3 | 9 |
| BALB/c | 16 | 1.0 ± 0.0 | 3 | 1.0 ± 0.0 | 3 |
| NOD.H2h4 | 16 | 18.6 ± 5.6 | 9 | 17.4 ± 3.0 | 6 |
The NOD.Lc7 strain (24) carries a segment on the distal end of Chr 7 which corresponds to the B10.A.4R interval retained in NOD.H2h4 mice (Fig. 5B). TgAb values are given as the standardized OD 490 nm in ELISA (see Methods). The extent of thyroiditis is given as the % lymphocytic infiltration of the gland; no infiltration is assigned the value 1.0 %. The number of mice (n) in each group is provided. Data for BALB/c and NOD.H2h4 mice are included as negative and positive values, respectively; NOD.H2h4 data are shown graphically in Fig. 1 and Fig. 2.