. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: Genes Immun. 2015 Mar 26;16(4):268–274. doi: 10.1038/gene.2015.7

Table 2.

The exon 10 haplotype of the thyroglobulin (Tg) gene (Chr 15) is not related to the development of spontaneous thyroid autoimmunity in NOD.H2^h4 or NOD mice. Examples are included of previously described Tg haplotypes for mouse strains susceptible, or resistant, to thyroiditis induced experimentally by immunization with mouse Tg and adjuvant (26).

Strain	Thyroiditis	Exon 10 haplotype	MHC	I-A	I-E
	Spontaneous
NOD.H2^h4	Yes	Asn-Val-Ile	H-2^k	I-A^k	ne
NOD	Yes (variable)	Asn-Val-Ile	H-2^g7	I-A^g7	ne
B10.A(4R)	No	Asn-Val-Ile	H-2^k	I-A^k	I-E^b
	Experimental
CBAJ, C3H/HeJ, AKR/J	Susceptible	Ser-Met-Thr	H-2^k	I-A^k	I-E^k
C57BL/6, BALB/cJ, DBA/2J	Resistent	Asn-Val-Ile	H-2^b	I-A^b	ne

Amino acid positions for the exon 10 haplotype (from Ref. (26): Asn-757, Val-808, Ile-919; Ser-757, Met-808, Thr-919. Information is provided for MHC, I-A and I-E; ne, not expressed.