Table 2.
Putative genes found exclusively in one or more strains of M. hominis isolated from cases of intra-amniotic infection
| Gene identifiera | Putative function | Additional information |
|---|---|---|
| AF3_360 | Type II restriction enzyme | |
| PL5_435 | Vmp | |
| AF1_110, AF3_18 | Type II restriction enzyme | |
| AF1_210, AF3_363 | Type II restriction enzyme | |
| AF1_231, PL5_326 | Vmp | |
| AF1_511-AF1_517, AF3_358-AF3_364 | Hypothetical proteins | Not present in PL5 |
| AF1_23, AF3_18, PL5_476 | Alanine racemase | amniotic fluid/placental isolate gene A (alr)* |
| AF1_212, AF3_405, PL5_34 | Hypothetical protein from U. urealyticum (low similarity). | amniotic fluid/placental isolate gene B (goiB)* |
| AF1_518, AF3_365, PL5_284 | Hypothetical protein | amniotic fluid/placental isolate gene C (goiC)* |
| AF1_135, AF3_121, PL5_112, MHO_1580 | Hypothetical protein | Present in PG21 but truncated due to nonsense mutation |
| AF1_330, AF3_184, PL5_343 | Cation-transporting ATPase, E1-E2 family | Present in PG21 but truncated due to nonsense mutation (not annotated) |
| AF1_401, AF3_251, PL5_156, MHO_4360 | ABC transporter ATP- binding protein | Present in PG21 but truncated due to nonsense mutation |
| AF1_248 AF3_442 PL5_555 | Hypothetical protein | Present in PG21 but truncated due to nonsense mutation (not annotated) |
The strains harboring the gene are listed. Amino acid and nucleotide sequences corresponding to the gene identifiers can be found through NCBI (Accession numbers CP009677, JRWZ00000000, and JRXA00000000).
The presence of these genes in vaginal swab samples and amniotic fluid samples was determined in this study.