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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Pharmacol Ther. 2015 Apr 4;151:141–151. doi: 10.1016/j.pharmthera.2015.04.002

Figure 2. A schematic illustration of how pro-TAME and Apcin inhibit the APC E3 ligase activity.

Figure 2

pro-TAME, an IR-mimetic, directly blocks the recruitment of APC coactivators including Cdc20 and Cdh1, to the APC core complex. On the other hand, Apcin occupies the D-box-binding pocket on the side of the WD40 domain of Cdc20 and therefore blocking substrate-induced Cdc20 loading onto the APC core complex.