Table 1. The different types degrons that are recognized by Cdh1 and Cdc20.

APCCdh1				APCCdc20
Degron	Consensus	Representative Substrates	References	Degron	Consensus	Representative Substrates	References
D-box	RxxLx(2-5)N/D/E	Cyclin A2, Plk1, Skp2, Geminin, Cdc6	(Bashir et al., 2004; den Elzen & Pines, 2001; Geley et al., 2001; Lindon & Pines, 2004; McGarry & Kirschner, 1998; Petersen et al., 2000; Wei et al., 2004)	D-box	RxxLx(2-5)N/D/E	Cyclin B1, Securin, etc.	(Clute & Pines, 1999; Michaelis et al., 1997; Nasmyth, 2001)
KEN box	KENxxD/Q/E/N	Geminin, Cdc6	(McGarry & Kirschner, 1998; Petersen et al., 2000)	TEK	TEK	Securin	(Jin et al., 2008)
A box	QRVL	Aurora A, Aurora B	(Littlepage & Ruderman, 2002)	ABBA Motif	KxxFxxYxDxxE	Cyclin A1, Cyclin A2	(Di Fiore et al., 2015)
O box	paspLtekNak	ORC1	(Araki et al., 2003)	LXPKXLF Motif	LXPKXLF	PHF8	(Lim et al., 2013)
GxEN	GxEN	X-kid	(Castro et al., 2003)	LR Motif	LR	Kif18A	(Sedgwick et al., 2013)
LLK	LLK	Claspin	(Gao et al., 2009)	MR Motif	MR	Nek2A	(Sedgwick et al., 2013)
CRY	CRY	Cdc20	(Reis et al., 2006)