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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Pharmacol Ther. 2015 Apr 4;151:141–151. doi: 10.1016/j.pharmthera.2015.04.002

Table 2. Summary of the identified ubiquitination substrates for APCCdc20.

Substrates Functions/signaling pathways of substrates Coactivators References
Bard1 Controls spindle pole formation Cdc20/Cdh1 (Song & Rape, 2010)
Bim Plays key roles in regulating apoptosis Cdc20 (Wan et al., 2014)
Cenp-F Functions in kinetochore and chromosome segregation in mitosis Cdc20 (Gurden et al., 2010)
Conductin Inhibits the Wnt signaling pathway Cdc20 (Hadjihannas et al., 2012)
Cyclin A Controls S phase and G2/M transition Cdc20/Cdh1 (den Elzen & Pines, 2001; Geley et al., 2001)
Cyclin B Activates Cdk1 and controls the G2/M transition Cdc20/Cdh1 (Clute & Pines, 1999)
E2F1 Governs G1/S transition and apoptosis Cdc20/Cdh1 (Budhavarapu et al., 2012)
Hmmr Regulates the localization of Tpx2 at the spindle pole Cdc20/Cdh1 (Song & Rape, 2010)
HURP Nucleates and crosslinks microtubules in the vicinity of chromatin Cdc20/Cdh1 (Song & Rape, 2010)
Id1 Inhibits dendrite growth Cdc20 (Kim, A. H. et al., 2009)
Kif18A Plays a role in chromosome congression Cdc20 (Sedgwick et al., 2013)
Mcl-1 Anti-apoptotic protein Cdc20 (Harley et al., 2010)
Mps1 Regulates the spindle assembly checkpoint and chromosome-microtubule attachments Cdc20/Cdh1 (Cui et al., 2010)
Nek1 Functions in primary cilium formation Cdc20 (Shalom et al., 2008)
Nek2A Regulates centrosome separation and spindle formation Cdc20 (Hames et al., 2001; Hayes et al., 2006)
NeuroD2 Inhibits presynaptic differentiation Cdc20 (Yang et al., 2009)
Nlp Functions in centrosome maturation Cdc20/Cdh1 (Wang & Zhan, 2007)
NuSAP Nucleates and crosslinks microtubules in the vicinity of chromatin Cdc20/Cdh1 (Song & Rape, 2010)
PHF8 Activates gene transcription by demethylating histon H3 and H4 Cdc20 (Lim et al., 2013)
p21Cip1 Inhibits cyclin-dependent kinase activity Cdc20 (Amador et al., 2007)
RAP80 Recruits BRCA1 to DNA damage sites Cdc20/Cdh1 (Cho et al., 2012)
REV1 Functions on replicating across DNA lesions at the stalled replication fork Cdc20/Cdh1 (Chun et al., 2013)
Securin Inhibits separase activity Cdc20/Cdh1 (Michaelis et al., 1997; Nasmyth, 2001)
Sp100 Participates in viral resistance, transcriptional regulation and apoptosis Cdc20 (Wang et al., 2011)
TRRAP Histone acetyltransferase complex component Cdc20/Cdh1 (Ichim et al., 2013)