| TAME |
Reduces Cdc20 association with the APC and subsequently inhibits APC activity. |
(Zeng et al., 2010) |
| Pro-TAME |
A TAME pro-drug, disrupts the APC-Cdc20 interaction and then reduces APC activation. |
(Zeng et al., 2010) |
| Apcin |
Occupies the D-box-binding pocket on the side of the WD40 domain, blocks substrate-induced Cdc20 loading onto the APC. |
(Sackton et al., 2014) |
| Withaferin A |
Enhances degradation of Cdc20, blocks SAC function, leading to mitotic delay. |
(Das et al., 2014) |
| NAHA |
Inhibits the expression of Cdc20 in breast cancer cells, retards cell proliferation and colony formation. |
(Jiang et al., 2012) |
| Ganodermanontriol, Mycophyto complex |
Down-regulates Cdc20 expression, inhibits cell proliferation and invasion in breast cancer cells. |
(Jiang et al., 2011; Jiang & Sliva, 2010) |
| Genistein |
Regulation of Cdc20 in various human cancers to exert its anti-tumor activity. |
(Regenbrecht et al., 2008; Shike et al., 2014; Zhang et al., 2015) |
| CFM-4 |
Down-regulates Cdc20 in breast cancer cells, induces apoptosis. |
(Puliyappadamba et al., 2011) |
| BCHHD 7c |
Inhibits Cdc20 expression in drug resistant pancreatic cancer cells. |
(Nasr et al., 2014) |
