Cost of chemotherapy regimens (including chemotherapy, trastuzumab, and growth factor support) in 2006, 2009 and 2014 for (A) trastuzumab-based regimens and (B) non–trastuzumab-based regimens. AC indicates doxorubicin and cyclophosphamide; ACTH, doxorubicin, cyclophosphamide, paclitaxel, and trastuzumab; TAC, docetaxel, doxorubicin, and cyclophosphamide; TC, docetaxel and cyclophosphamide; TCH, docetaxel, carboplatin, and trastuzumab.