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. Author manuscript; available in PMC: 2015 Dec 4.
Published in final edited form as: Nature. 2015 Apr 6;522(7554):94–97. doi: 10.1038/nature14306

Figure 2. β-catenin activation not sufficient to overcome extrinsic gradient of basal epithelial survival.

Figure 2

a) Wnt/β-catenin activation is restricted to inner layers. Immunofluorescent staining of Lef1 in regressing hair follicle. Lef1 (red) and P-cadherin (green). b) Scheme of basal and inner layer behaviors and β-catenin activation during hair follicle regression. c) Lineage tracing of basal epithelial cells revisited at the beginning and end of regression. Representative examples of either a single control or β-catenin activated cell traced during regression. d) Graphical representation of cell survival as a function of initial position within the regressing hair follicle (n = 235 or 135 in control or β-catenin, respectively, in 4 mice). Scale bars, 25 μm.