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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: J Pathol. 2015 Apr 8;236(3):384–394. doi: 10.1002/path.4530

Fig.2. Lung mesenchymal TGF-β signal at late fibrotic stage, but not early inflammatory stage, contributed to lung fibrosis.

Fig.2

(A) Lung mesenchymal TGF-β signaling was inhibited at different stages in BLM-induced lung fibrosis by controlling Dox-induced dnTβRII expression as indicated; I-1: 7 days before BLM to day 28 after BLM, I-2: 7 days before BLM to day 7 after BLM, I-3: Day 7 to day 28 after BLM, I-4: Day 14 to day 28 after BLM. (B) Fibrotic histopathology was shown by H&E-stained lung tissue sections, with indicated genotypes and Dox induction scheme. (C) Fibrotic changes were quantitatively compared using Ashcroft scores among the lungs with dnTβRII-mediated inhibition at different stages after BLM injury. *P<0.05.