Figure 4. Hyperoxia-induced immune cell accumulation was suppressed in mice administered with Ad-SOCS-1.
Male and female C57Bl/6 mice transfected with recombinant Ad-SOCS-1 and Ad-GFP were exposed to room air (Normoxia) or 100% O2 (Hyperoxia) at 72 h as described in Material and Methods. After 72 h exposure, BALF was extracted from mice and analyzed for (A) total cells, (B) macrophages, and (C) neutrophils by manual count. *P < 0.05 when compared between Ad-GFP- and Ad-SOCS-1-transfected mice under hyperoxia.