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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Neuropharmacology. 2014 Dec 5;95:100–109. doi: 10.1016/j.neuropharm.2014.11.024

Figure 5.

Figure 5

Effect of CB1 and CB2 receptor antagonists on the antinociceptive effect of i.p. URB597. Sensory behaviors (tactile allodynia: A and B; cold allodynia: C and D; mechanical hyperalgesia: E and F were evaluated 15 and 90 min after co-adminstration of URB597 and CB1 antagonist AM251 (A,C,and E) or CB2 antagonist SR144528 (B,D, and F), or vehicle. Higher doses of CB1 and CB2 antagonists were assessed by themselves and in combination with URB597. Data are expressed as mean ± SEM (n = 8–11 animals per treatment group). Asterisks show the differences compared with vehicle injected group. *: p<0.05, **: p<0.01, ***: p<0.001.