Skip to main content
. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Ann Epidemiol. 2015 Jan 31;25(7):492–498. doi: 10.1016/j.annepidem.2015.01.010

Table 2.

Results of individual regression models by cohort, each adjusted for age and gender.

Variable Original cohort (PLT) Offspring (PRPPC) Third Generation (PLT) Third Generation (MPV)
Parameter P-value Parameter P-value Parameter P-value Parameter P-value
Gender (female)a 30.88b <.0001 825.82 0.0008 23.35 <.0001 0.0687 0.0657
Age, yearsc 0.38 0.3574 −37.24 0.0026 −0.19 0.1477* −0.0044 0.041
Hypertension medication −2.93 0.5435 269.39 0.4049 10.06 0.0008* −0.0094 0.851
Smoked cigarettes regularly (last year) 34.90 <.0001 1,377.61 <.0001 14.83 <.0001 −0.1147 0.0474
Current smokerd 35.28 <.0001 1,338.98 0.0002 15.35 <.0001 −0.1300 0.0278
Former smokerd 6.96 .1617 81.16 0.7668 11.17 0.2332 −0.0900 0.5462
Pack years (ln) 7.79 0.0403 574.98 <.0001 --- ---
Alcohol use 1.54 0.755 31.95 0.9052* −3.09 0.2708 −0.0312 0.5042
Aspirin use 1.09 0.8309* 476.81 0.0962 0.35 0.9172 0.1287 0.0204
Diabetes (prevalence) 1.85 0.8043 −1,479.86 0.0023 4.97 0.2722* 0.1572 0.0369
Diabetes medication −11.82 0.1987 −2,498.73 0.0003 12.39 0.0297 0.0928 0.3284
PE/DVT (prevalence) ---e 1,043.95 0.6891 35.22 0.0045 −0.0837 0.685
CVD (prevalence) −3.67 0.4797 −383.07 0.3675 1.25 0.8588** 0.0686 0.5579
CVA (prevalence) −13.01 0.0984 −1,171.41 0.231 −10.88 0.3916 0.0238 0.9104
SBP (mmHg) 0.06 0.6069 22.55 0.0011* 0.37 <.0001* 0.0004 0.7866
DBP (mmHg) −0.19 0.3895 49.74 <.0001 0.64 <.0001* 0.0004 0.8458
HDL (mg/dL) 0.30 0.0721 −1.75 0.8441* −0.16 0.0235** −0.0008 0.4884
LDL (mg/dL) --- 22.26 <.0001 0.28 <.0001 −0.0016 0.0084
Triglycerides (mg/dL) --- 4.42 0.0003 0.09 <.0001 −0.0003 0.0265
Total cholesterol (mg/dL) 0.23 0.0001 25.33 <.0001 0.26 <.0001*** −0.0020 0.0003
PLT(×103/uL) --- --- --- −0.0069 <.0001
MPV (fL) --- --- −25.04 <.0001 ---
BMI −0.06 0.902 34.65 0.1592 1.03 <.0001** 0.0053 0.1033
Antiplatelets −9.86 0.4558 −1,335.37 0.5097 --- ---
Anticoagulants 4.56 0.7678 −1,573.50 0.2122 --- ---
a

Adjusted for age only,

b

Values in bold are significant after Bonferroni correction (p<6.67×10−4),

c

Adjusted for gender only,

d

“Current” and “former” smoking were part of a three-level variable in an individual regression model, with “never” smoker considered the referent value.

See “Methods” section for more.

e

“---” indicates PE/DVT, LDL cholesterol, triglycerides, PLT, MPV, pack years, or antiplatelets and anticoagulants were unavailable for these exams.

See “Methods” section for more.

*

,**,*** indicates significant interaction term with gender (*0.01≤p<0.05, **0.001≤p<0.01, ***p<0.001)