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. 2015 Jun 5;10(6):e0129314. doi: 10.1371/journal.pone.0129314

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© 2015 Ghaleb et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — A. IHC shows decreased baseline levels of p65 subunit of NF-κB in Iqgap2 ^-/- colon compared to WT (panels a, d). While DSS treatment resulted in elevated levels of p65 in WT colon, it failed to elicit the same response in Iqgap2 ^-/- colon (panel b, e). Termination of DSS treatment results in a restoration of the baseline p65 levels within 7 days in both genotypes (panel c, f). B. IHC of TLR4 in WT and Iqgap2 ^-/- colons before and after DSS treatment. C. IHC of MyD88 in the same samples. Note low levels of both TLR4 and MyD88 in Iqgap2 ^-/- colons after DSS exposure (panels d). A representative image of N = 5 per genotype is shown for each IHC. Magnification is 200 X.