Table 5. Risk of skeletal fluorosis associated with GSTP1 Rs1695 in subjects, stratified by fluoride exposure levels.
| Non high-loaded fluoride status | High-loaded fluoride status | ||||||
|---|---|---|---|---|---|---|---|
| Case (n) | Control (n) | OR (95% CI)* | Case (n) | Control (n) | OR (95% CI)* | p | |
| All subjects | 0.204 | ||||||
| AA | 82 | 376 | 1.0 (ref) | 144 | 305 | 1.0 (ref) | |
| AG+GG | 32 | 203 | 0.736 (0.463, 1.168) | 89 | 183 | 1.031 (0.737, 1.442) | |
| Tibetan | 0.445 | ||||||
| AA | 16 | 34 | 1.0 (ref) | 75 | 83 | 1.0 (ref) | |
| AG+GG | 5 | 25 | 0.426 (0.129, 1.406) | 27 | 43 | 0.622 (0.339, 1.144) | |
| Kazakh | 0.004 | ||||||
| AA | 15 | 11 | 1.0 (ref) | 37 | 95 | 1.0 (ref) | |
| AG+GG | 3 | 13 | 0.166 (0.035, 0.780) | 43 | 74 | 1.487 (0.866, 2.552) | |
| Mongolian | 0.789 | ||||||
| AA | 17 | 86 | 1.0 (ref) | 18 | 51 | 1.0 (ref) | |
| AG+GG | 8 | 37 | 1.043 (0.408, 2.669) | 14 | 29 | 1.359 (0.581, 3.183) | |
| Han | 0.602 | ||||||
| AA | 30 | 198 | 1.0 (ref) | 9 | 57 | 1.0 (ref) | |
| AG+GG | 13 | 90 | 1.140 (0.554, 2.343) | 5 | 23 | 1.536 (0.448, 5.268) | |
| Russians | 0.139 | ||||||
| AA | 4 | 47 | 1.0 (ref) | 4 | 19 | 1.0 (ref) | |
| AG+GG | 3 | 38 | 1.260 (0.243, 6.550) | 0 | 15 | - | |
* Adjusted for age, sex, ethnicity, and IF. p value testing heterogeneity.