Fig 4. GSIs inhibit SPP/SPPLs in a dose-dependent manner.
FBA/SPPLs co-transfected HEK cells were treated with DMSO or GSIs as appropriate. Twenty-four hours later the medium was collected for assay by Aβ ELISA. xAβ1-25/K16A levels from DMSO-treated cells served as the control. All tests were repeated 3 times. Data were analyzed using GraphPad.