Table 3. IC50s (nM) of select GSI on FBA/SPPL co-transfected cells.
| (Z-LL)2 ketone | LY-411,575 | L685,458 | GSI II | Compound E | DBZ | |
|---|---|---|---|---|---|---|
| SPPL2a | 177±99 (2) | 51±79 (1) | 570±90 (3) | 8802±94 (4) | - | - |
| SPPL2b | 2141±143 (2) | 5499±122 (4) | 876±133 (1) | 3604±121(3) | - | - |
| hSPP | 519±97 (4) | 150±106 (1) | 319±91(2) | 423±92 (3) | 1465±93 | 948±93 |
| pSPP | 472±114 (3) | 3479±90 (4) | 161±97 (1) | 427±100 (2) | - | - |
Each assay was repeated at least 3 times. The values in the table are the means ± standard errors. Numbers in parenthesis represent the rank order of inhibition of each SPP/SPPL by each compound.