Fig 7. HIF-1α expression in CD11c⁺ cells exacerbates disease.

Hif-1α ^flox/flox Cd11c-Cre ^- and Hif-1α ^flox/flox Cd11c-Cre ⁺ mice were infected i.v. with 2x10⁷ PINK L. donovani amastigotes. (A) Graph represents the splenic parasite burden expressed as Leishman Donovan Units (LDU) at various time points after infection. (B) The splenic parasite burden was determined by limiting dilutions at d 14 p.i. (C) Graph represents the hepatic parasite burden at different times of infection. (D) Graph shows the splenic parasite burden at d14 p.i. in infected Hif-1α ^flox/flox Cd11c-Cre ^- and Hif-1α ^flox/flox Cd11c-Cre ⁺ mice; mice were treated or not with the anti-CD8 antibody clone 2.43. All data is presented as the mean ± SEM, n = 5. * denotes p<0.05, ** denotes p<0.01 and *** denotes p<0.001.