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. 2015 Jun 5;10(6):e0128828. doi: 10.1371/journal.pone.0128828

Table 4. The summary of proteolytic cleavage result affected by a series of substitution in this study.

mutation type Ala-substitution Asp- substitution
position S538 Y611 T674 S538Y611 S538T674 Y611T674 S538Y611T674 S538 Y611 T674 S538Y611 S538T674 Y611T674 S538Y611T674
result + + - + - - - + - - - - - -

Note:

“+” means such mutation does not affect intermediate precursor VP4-VP3 cleavage;

“-” means such mutation affects intermediate precursor VP4-VP3 cleavage.