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. 2015 Jun 5;10(6):e0129267. doi: 10.1371/journal.pone.0129267

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© 2015 Ligeti et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — The effects of two drugs (Drug1, Drug2) reach their imminent targets first (arrows) and the effects will then propagate to their network neighborhoods (subnetworks) indicated in red and green, respectively. Targets in the overlap are affected by both drugs, and we suppose that drugs affecting a number of common targets will influence the effects of each other. The overlap is quantified as the proportion of jointly affected targets within all affected targets (in set theory terms: intercept divided by union).