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. 2015 Jun 5;10(6):e0129267. doi: 10.1371/journal.pone.0129267

Fig 2. Ranking performance of the TOS score on known drug interactions and therapeutic combinations.

Fig 2

The ranking performance was measured via ROC analysis as described in Data and Methods. The standard deviation of AUC values (not shown) are between 0.0001 and 0.006 for the different datasets. Note that the tendencies of drug combination groups are the same between cancer-related and not cancer-related drugs. Also, combinations of drugs with identical targets or with similar chemical structures give high TOS scores. These combinations were left out from the statistics of the other groups so they do not influence the AUC values of the other groups.