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. 2015 Jun 2;21(6):845–854. doi: 10.1016/j.cmet.2015.04.016

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Amelioration of Mitochondrial Ultrastructure in Cox15^sm/sm::Opa1^Tg Skeletal Muscle

(A) EM microphotographs of specimens from the different genotypes. Note that while there is accumulation of inter-myofibrillar amorphous material and disorganization of the mitochondrial cristae (inset) in the Cox15^sm/sm, the myofibrillary array and cristae structure (inset) are both well preserved in the Cox15^sm/sm::Opa1^Tg. Mitochondria appear larger and with denser cristae in Opa1^Tg than in WT. Scale bar 2 μm; scale bar of the inset: 200 nm.

(B) Morphometric quantification of the area, perimeter, length and width of mitochondria from the different genotypes. A total of 200 mitochondria from WT and Opa1^Tg mice (n = 2) were analyzed, and 500 from Cox15^sm/sm and Cox15^sm/sm::Opa1^Tg (n = 2).