Table 1. Clinical data of patients enrolled in the study.
| Patients | Gender | EDSS at LP time | ΔEDSS at 5 years fu | Relapse N° at 5 years fu | RR at 5 years fu | DMT at 2 years fu | DMT at 5 years fu | Clinical class. at 2 years fu | Clinical class. at 5 years fu | Final diagnosis |
|---|---|---|---|---|---|---|---|---|---|---|
| MS25 | F | 6 | 0 | 0 | 0 | none | none | PPMS | PPMS | PPMS |
| MS26 | F | 1 | 1* | 1* | 0.2* | I | death | M | death | RRMS |
| MS27 | F | 1 | 2.5 | 4 | 0.8 | II | II | H | H | RRMS |
| MS28 | F | 1.5 | 5 | 3 | 0.6 | I | II | M | H | RRMS |
| MS29 | F | 6 | 0 | 3 | 0.6 | II | II | H | H | RRMS |
| MS30 | F | 1 | 0 | 1 | 0.2 | I | I | M | M | RRMS |
| MS31 | F | 0 | 1 | 3 | 0.6 | none | I | L | M | RRMS |
| MS32 | F | 1.5 | 0,5 | 1 | 0.2 | I | I | M | M | RRMS |
| MS33 | F | 0 | 1 | 2 | 0.4 | I | I | M | M | RRMS |
| MS34 | F | 0 | 0 | 0 | 0 | none | none | L | L | RRMS |
| MS35 | F | 1 | 1 | 2 | 0.4 | I | I | M | M | RRMS |
| MS36 | F | 1 | 0 | 0 | 0 | none | none | L | L | RRMS |
| MS37 | F | 0 | 1 | 0 | 0 | I | I | M | M | RRMS |
| MS38 | F | 1 | 0 | 2 | 0.4 | I | I | M | M | RRMS |
| MS39 | F | 1.5 | 0 | 0 | 0 | none | none | L (B) | L (B) | Benign MS |
| MS40 | F | 1 | 0 | 1 | 0 | none | none | L (B) | L (B) | Benign MS |
| MS41 | F | 3.5 | 0** | lost | lost | *** | lost | lost | lost | RRMS** |
| MS42 | F | 0 | 1 | 1 | 0.2 | I | I | M | M | RRMS |
| MS43 | F | 4 | 0 | ? | ? | I | I | M | M | RRMS |
| MS44 | F | 2 | 0 | 3 | 0.6 | II | II | H | H | RRMS |
| MS45 | F | 0 | 0 | 0 | 0 | none | none | L | L | RRMS |
| MS46 | F | 0 | 0 | 2 | 0.4 | I | I | M | M | RRMS |
| MS47 | F | 2 | 0 | 4 | 0.8 | II | II | H | H | RRMS |
| MS48 | F | no MS | no MS | no MS | no MS | no MS | no MS | no MS | no MS | Somatoform disorder |
F = female; LP = lumbar puncture time; EDSS = Expanded Disability Status Scale; ΔEDSS = difference between EDSS assessment at the diagnosis after 5 years of follow-up; fu = follow-up; RR = relapse-rate; DMT = disease-modifying treatments, indicated as: first line (I), second line (II) pharmacological treatments or absence of therapy (none). Clinical class. = clinical classification according: H (high) = highly aggressive disease, second-line therapy; M (moderate) = moderately aggressive disease, first-line therapy; L (low) = mildly aggressive disease; L (B) = “benign” disease, characterized by absence or progression no therapy. PPMS = primary progress multiple sclerosis; RRMS = relapsing remitting multiple sclerosis
* data available at 2-year follow-up
** data available at 1-year follow-up
*** no therapy prescribed at diagnosis.