Table 3.
Effects of comorbidity, medication, and contrast dose on KIM-1 and N-GAL excretion
| Variable | Median KIM-1 ratio (2.5-97.5 percentiles) | P-value | Median N-GAL ratio (2.5-97.5 percentiles) | P-value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 4-6 h | 48-96 h | Baseline | 4-6 h | 48-96 h | |||||||||
| Age | ||||||||||||||
| > 75 years | 1.2 | (0.1-6.3) | 1.2 | (0.1-8.1) | 1.4 | (0.1-7.9) | 0.58 | 44.4 | (5.0-3403.0) | 54.8 | (6.9-4336.2) | 41.9 | (3.1-3867.3) | 1.0 |
| < 75 years | 1.2 | (0.1-8.3) | 1.3 | (0.1-10.4) | 1.3 | (0.1-13.9) | 39.25 | (4.1-2965.0) | 43.1 | (4.5-2614.1) | 36.0 | (3.7-3122.8) | ||
| Severe CKD | ||||||||||||||
| Present | 1.9 | (0.1-11.7) | 1.3 | (0.2-8.9) | 1.9 | (0.1-9.3) | 0.16 | 239.1 | (7.2-3734.5) | 190.3 | (13.2-4486.3) | 176.5 | (10.3-5341.3) | 0.84 |
| Absent | 1.2 | (0.1-6.9) | 1.3 | (0.1-8.6) | 1.3 | (0.1-8.0) | 38.1 | (4.3-2523.9) | 44.1 | (5.6-2529.1) | 33.9 | (3.4-2251.1) | ||
| Diabetes mellitus | ||||||||||||||
| Present | 1.4 | (0.1-6.6) | 1.3 | (0.2-8.0) | 1.4 | (0.1-6.9) | 0.41 | 51.6 | (7.0-2714.5) | 49.9 | (8.6-2661.9) | 43.7 | (6.4-2010.2) | 0.66 |
| Absent | 1.1 | (0.1-11.2) | 1.3 | (0.1-1.3) | 1.3 | (0.1-8.9) | 39.5 | (3.9-3224.1) | 48.5 | (5.6-3702.9) | 32.6 | (2.8-4584.2) | ||
| Congestive heart failure | ||||||||||||||
| Present | 1.5 | (0.1-6.6) | 1.6 | (0.1-9.9) | 1.9 | (0.1-7.7) | 0.98 | 39.5 | (5.9-1162.2) | 45.5 | (2.4-1199.4) | 43.5 | (2.5-722.7) | 0.71 |
| Absent | 1.2 | (0.1-8.9) | 1.2 | (0.1-8.6) | 1.3 | (0.1-8.7) | 41.1 | (4.2-3291.3) | 49.9 | (6.0-4086.2) | 37.1 | (3.7-3927.8) | ||
| Coronary artery disease | ||||||||||||||
| Present | 1.3 | (0.1-6.4) | 1.3 | (0.1-8.3) | 1.5 | (0.2-7.7) | 0.56 | 34.9 | (4.8-4012.5) | 42.6 | (5.2-4198.7) | 32.3 | (2.5-2003.4) | 0.80 |
| Absent | 1.1 | (0.1-11.7) | 1.3 | (0.1-10.6) | 1.3 | (0.1-9.1) | 44.5 | (4.3-3216.7) | 50.3 | (6.0-3304.7) | 42.2 | (4.6-4477.4) | ||
| Peripheral artery disease | ||||||||||||||
| Present | 1.3 | (0.1-6.3) | 1.4 | (0.1-7.7) | 1.3 | (0.1-7.2) | 0.99 | 35.0 | (3.9-760.8) | 44.6 | (5.8-1383.1) | 32.1 | (2.6-1140.9) | 0.77 |
| Absent | 1.2 | (0.1-10.5) | 1.2 | (0.1-10.5) | 1.3 | (0.1-8.5) | 42.4 | (4.4-3703.5) | 49.2 | (5.7-4593.8) | 39.5 | (3.9-4680.3) | ||
| NSAIDs use | ||||||||||||||
| Present | 1.2 | (0.1-2.4) | 1.0 | (0.1-8.4) | 0.8 | (0.1-4.2) | 0.81 | 43.2 | (5.0-614.5) | 49.6 | (3.5-842.4) | 49.1 | (5.4-633.1) | 0.91 |
| Absent | 1.2 | (0.1-7.7) | 1.3 | (0.1-8.5) | 1.4 | (0.1-8.1) | 40.1 | (4.3-3216.7) | 48.7 | (5.7-3600.9) | 37.1 | (3.4-3741.2) | ||
| Diuretic use | ||||||||||||||
| Present | 1.4 | (0.1-7.6) | 1.4 | (0.2-8.2) | 1.5 | (0.1-7.0) | 0.98 | 38.6 | (5.0-1511.4) | 36.7 | (6.0-2499.2) | 31.5 | (3.2-2688.5) | 0.71 |
| Absent | 1.1 | (0.1-11.1) | 1.2 | (0.1-10.7) | 1.3 | (0.1-9.1) | 41.7 | (3.9-3976.3) | 56.8 | (5.4-4785.5) | 43.7 | (3.8-3916.6) | ||
| Contrast dose* | ||||||||||||||
| High | 2.1 | (0.2-11.9) | 1.6 | (0.2-18.7) | 1.9 | (0.2-12.0) | 0.29 | 68.4 | (5.4-7919.6) | 88.1 | (8.5-5885.2) (8.5 | 55.3 | (6.7-8300.8) | 0.72 |
| Low | 1.1 | (0.1-6.8) | 1.2 | (0.1-8.4) | 1.3 | (0.1-7.9) | 38.3 | (4.3-2417.1) | 43.6 | (5.2-2514.1) | 36.5 | (3.4-2157.7) | ||