Table 1.
Clinical data
| Parameter units | Severe malaria | Cerebral malaria | p-value | |||
|---|---|---|---|---|---|---|
| Result | Mean (SD) | Result | Mean (SD) | Severe malaria vs cerebral malaria | ||
| Parasitemia | Parasites/μl | 114 | 97,111 (1,271,985) | 24 | 139,743 (683,264) | NSd |
| Pulse | /min | 120 | 126 (22) | 24 | 132 (21) | NSc |
| Temperature | Celsius | 120 | 38.3 (1.24) | 24 | 37.9 (1.17) | NSc |
| Respiratory rate | /min | 120 | 37.1 (11.5) | 24 | 42.9 (12.3) | 0.027c |
| Hemoglobin | g/dl | 119 | 8.7 (2.3) | 24 | 8.3 (2.7) | NSc |
| Platelets | 1000/ μl | 119 | 109.310 (94.924) | 24 | 67.458 (50.113) | 0.016d |
| White blood cells | 1000 /μl | 119 | 9.7 (6.7) | 24 | 10.2 (4.1) | NSd |
| Glucose | mmol/l | 98 | 5.169 (2.342) | 20 | 4.895 (2.521) | NSc |
| Creatinine | g/l | 96 | 23.5 (91)b | 18 | 31.5 (568)b | NSd |
| Bilirubin | g/l | 99 | 27.5 (184)b | 21 | 29 (77)b | NSd |
| ALT | U/l | 101 | 32.2 (33.4) | 20 | 34.9 (26.9) | NSd |
| Hemoglobinuria | % of included patients | 119 | 1.7 % | 24 | 4.2 % | NSe |
| Respiratory distress | % of included patients | 119 | 4.2 % | 24 | 12.5 % | NSf |
| Deep breathing | % of included patients | 120 | 1.7 % | 24 | 0 % | NSf |
| Severe vomiting | % of included patients | 119 | 2.5 % | 24 | 4.2 % | NSf |
| Prostration | % of included patients | 119 | 16.8 % | 24 | 54.2 % | 0.000f |
| Coma | % of included patients | 119 | 0 % | 24 | 37.5 % | 0.000f |
| Repeated generalized seizures | % of included patients | 119 | 0 % | 24 | 50 % | 0.000f |
| Jaundice | % of included patients | 119 | 4.2 % | 24 | 12.5 % | NSf |
| Severe anemia | % of included patients | 119 | 10.1 % | 24 | 20.8 % | NSe |
| Hypoglycemia | % of included patients | 119 | 2.5 % | 24 | 8.3 % | 0.03e |
The results of the evaluated clinical data are listed for patients with severe malaria and with cerebral malaria
Mean and standard deviation are given for continuous variables; comparison between groups has been performed by the indicated tests. NS, not significant
aGeometric mean (range); bmedian (range); cStudents t-test; dMann–Whitney U test; echi-square test; fFisher’s exact test