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. 2015 May 20;13:161. doi: 10.1186/s12967-015-0519-8

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© Chang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Antigen-stimulated CAR-T cells undergo selective expansion of the CAR^hi compartment. CFSE-labeled, CD8⁺ CAR-expressing cells or mock-transduced (CAR⁻) T cells were co-incubated with parental (CD19⁻) or CD19⁺ K562 targets without exogenous cytokines and monitored for a total T-cell count (left red axis) and CAR^hi or CAR^lo as a fraction of total CAR-T cells (right black axis), b median CFSE intensity, and c Annexin V staining. Average values of triplicates are shown with error bars indicating ± 1 standard deviation (s.d.)