Fig. 4.

Ancestral relationships of the new GO terms created to support detailed ASD-relevant annotations in the domain of synapse organization. A subsection of the ‘synapse organization’ domain ontology, human protein families (blue ovals) and their associated GO terms (green boxes), linked with red dotted line (see Additional files 5 and 8); all associations (except IEA-supported data) are included. If one or several member(s) of a protein family is associated with a specific term then the family name, or the protein name DLG4, is listed below the term. * indicates new GO terms (Table 1). Black arrows indicate an ‘is_a’ relationship between a term and its parent; blue arrows indicate a ‘part_of’ relationship