Table 1.

New GO terms created to support detailed ASD-relevant annotations. The ancestral relationship of these new GO terms is described in Figs. 4 and 5 (with the exception of the new protein binding terms and ‘receptor localization to synapse’). The term records in the QuickGO browser (http://www.ebi.ac.uk/QuickGO) provide the full definition and ontology placement for each GO term provide the full definition and ontology placement for each GO term. The reference column lists the references used as a source of information when creating each term

New GO Term	GO ID	Reference
Synapse assembly terms
Postsynaptic density assembly	GO:0097107	[65]
Postsynaptic density organization	GO:0097106	[65]
Postsynaptic membrane assembly	GO:0097104	[39]
Presynaptic membrane assembly	GO:0097105	[56, 68]
Presynaptic membrane organization	GO:0097090	[49]
Regulation of postsynaptic membrane potential terms
Negative regulation of excitatory postsynaptic membrane potential	GO:0090394	[49]
Positive regulation of excitatory postsynaptic membrane potential	GO:2000463	[77]
Positive regulation of inhibitory postsynaptic membrane potential	GO:0097151	[68]
Protein clustering/localization terms
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	GO:0097113	[35]
Gamma-aminobutyric acid receptor clustering	GO:0097112	[48]
Gephyrin clustering involved in postsynaptic density assembly	GO:0097116	[48]
Guanylate kinase-associated protein clustering	GO:0097117	[48]
Neurexin clustering involved in presynaptic membrane assembly	GO:0097115	[35]
Neuroligin clustering involved in postsynaptic membrane assembly	GO:0097118	[35]
N-methyl-D-aspartate receptor clustering	GO:0097114	[48]
Postsynaptic density protein 95 clustering	GO:0097119	[80]
Receptor localization to synapse	GO:0097120	[65]
Protein binding terms
Neuroligin family protein binding	GO:0097109	[39]
Scaffold protein binding	GO:0097110	[80]