Table 2.

Biological process behavioral GO terms associated with the ASD-relevant human and mouse proteins

	Human												Mouse
GO term name	NLGN3	NLGN4X	NLGN4Y	NRXN1-α	NRXN1-β	NRXN2-α	NRXN3-α	NRXN3-β	CNTNAP2	SHANK1	SHANK2	SHANK3	Nlgn2	Nlgn3	Nlgn4l	Nrxn1-α	Dlg4	Shank1	Shank2	Shank3
adult behavior	X	X		X	X	X	X	X	X	X	X	X				X			X
learning	X	X	X	X	X		X	X	X		X	X				X			X	X
social behavior	X	X	X	X	X	X	X	X	X	X	X	X		X	X		X	X	X	X
vocalization behavior	X	X	X	X	X	X	X	X	X	X	X	X			X		X	X	X	X
vocal learning				X		X			X			X
locomotory exploration behavior													X				X			X
visual learning														X
male courtship behavior															X
territorial aggressive behavior															X
regulation of grooming behavior																X	X			X
associative learning																		X
habituation																		X
long-term memory																		X
olfactory behavior																		X
memory																			X	X
exploration behavior																			X
regulation of behavioral fear response																				X

X indicates the existence of an association between the GO term and the protein record, based on behavioral traits associated with variant genes only (IMP, Inferred from Mutant Phenotype, or IGI, Inferred from Genetic Interaction, supported annotations, see Additional files 5 and 8)