Fig. 4.

Analysis of primary structure of T cell receptor (TCR) β complementarity-determining region 3 (CDR3) sequences. a Vβ and Jβ gene usage by expanded clones (size >0.1 %) from systemic lupus erythematosus (SLE) patients. The area of each bubble corresponds to the relative size of each clone. None of the CDR3 amino acids sequences were overlapping. b The amount of sequences that overlap in the repertoire across time points as a proportion of unique reads or total reads in healthy controls (HC) and SLE patients. Mean values with error bars depicting + standard deviation (SD) are shown (Mann–Whitney test)