Table 3.
Differential allelic ratio groups between local recurrence and control
| A) | Local recurrence group | Control group | ||||||
|---|---|---|---|---|---|---|---|---|
| Chr. | p-value | BH | Retention | Imbalance | LOH | Retention | Imbalance | LOH |
| 1q | 0.05 | 0.17 | 89% | 11% | 0% | 45% | 53% | 2% |
| 4q | 0.05 | 0.17 | 78% | 22% | 0% | 47% | 22% | 31% |
| 7p | 0.0005 | 0.015 | 100% | 0% | 0% | 36% | 62% | 2% |
| 7q | 0.0007 | 0.015 | 100% | 0% | 0% | 9% | 13% | 78% |
| 10p | 0.04 | 0.17 | 89% | 11% | 0% | 53% | 45% | 2% |
| 11p | 0.04 | 0.17 | 89% | 11% | 0% | 49% | 42% | 9% |
| 13q | 0.04 | 0.17 | 78% | 11% | 11% | 27% | 60% | 13% |
| 14q | 0.017 | 0.17 | 78% | 22% | 0% | 40% | 22% | 38% |
| 15q | 0.03 | 0.17 | 78% | 22% | 0% | 29% | 29% | 42% |
| 16q | 0.06 | 0.18 | 89% | 11% | 0% | 53% | 36% | 11% |
| 17p | 0.03 | 0.17 | 22% | 33% | 44% | 9% | 13% | 78% |
| 18q | 0.05 | 0.17 | 11% | 22% | 67% | 9% | 13% | 78% |
| 22q | 0.04 | 0.17 | 78% | 11% | 11% | 33% | 31% | 36% |
| B) | Local recurrence group | Control group | ||||||
| Chr. | p-value | Retention | Imbalance | LOH | Retention | Imbalance | LOH | |
| 7 | 0.0025 | 9 | 0 | 0 | 19 | 25 | 1 | |
| 13 | 0.0062 | 7 | 1 | 1 | 12 | 27 | 6 | |
| 7 + 13 | <0.0002 | 7 | 1 | 1 | 5 | 33 | 7 | |
A) For comparison of the local recurrence group and control group, chromosome arms are listed that showed significant allelic ratio groups with p-values <0.05 and adjusted p-values <0.2.
Abbreviations: Chr, chromosome; B, p-value after using the Benjamin-Hochberg method for multiple testing correction.
B) For chromosome 7, chromosome 13 and in combination, the numbers of patients within each ‘overall chromosome status’ group - defined as the most abundant allelic ratio group on the chromosome - are shown for both the local recurrence group (L) and the control group (C). Fisher’s exact test for count data was used to determine the statistical differences between analysis groups L and C.