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. 2015 May 14;6:21. doi: 10.1186/s13227-015-0007-5

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© Mansfield et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Development of the perineural sheath. In all panels, the neural tube is to the right. In panels (A-E), myotome is adjacent to (left of) the perineural sheath, and in panels (F-G), sclerotome-derived mesothelium is present between the myotome and perineural sheath (see text). The perineural sheath develops at the interface between them. A basal lamina is first apparent in 2 GS larvae (C). The black arrowhead in (E) indicates striated collagen fibers, first apparent at the 9 GS stage, and the white asterisk in (F) marks the nucleus of a sclerotome-derived mesothelial cell. All panels are to the scale shown. Stage abbreviations: neur, neurula; GS, gill slit; met, early metamorphosis; adult, subadult.